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Article

RhoA activation and nuclearization marks loss of chondrocyte phenotype in crosstalk with Wnt pathway.

Experimental cell research - 15 Nov 2017

Öztürk Ece, Despot-Slade Evelin, Pichler Michael, Zenobi-Wong Marcy

Abstract excerpt

De-differentiation comprises a major drawback for the use of autologous chondrocytes in cartilage repair. Here, we investigate the role of RhoA and canonical Wnt signaling in chondrocyte phenotype. Chondrocyte de-differentiation is accompanied by an upregulation and nuclear localization of RhoA. Effectors of canonical Wnt signaling including β-catenin and YAP/TAZ are upregulated in de-differentiating chondrocytes...

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Identifiers

PMID: 28865751
DOI: 10.1016/j.yexcr.2017.08.033

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