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Article

Interactions between Sox9 and beta-catenin control chondrocyte differentiation.

Genes & development - 1 May 2004

Akiyama Haruhiko, Lyons Jon P, Mori-Akiyama Yuko, Yang Xiaohong, Zhang Ren, Zhang Zhaoping, Deng Jian Min, Taketo Makoto M, Nakamura Takashi, Behringer Richard R, McCrea Pierre D, de Crombrugghe Benoit

Abstract excerpt

Chondrogenesis is a multistep process that is essential for endochondral bone formation. Previous results have indicated a role for beta-catenin and Wnt signaling in this pathway. Here we show the existence of physical and functional interactions between beta-catenin and Sox9, a transcription factor that is required in successive steps of chondrogenesis. In vivo, either overexpression of Sox9 or inactivation of...

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Identifiers

PMID: 15132997
DOI: 10.1101/gad.1171104
PMCID: PMC406296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interactions between Sox9 and beta-catenin control chondrocyte differentiation.PMID 15132997Read ↗

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SOX9 and the many facets of its regulation in the chondrocyte lineageSemantic proximity Read ↗

Sox9 is required for cartilage formation.Semantic proximity Read ↗

Regulation of Cartilage Development and Diseases by Transcription FactorsSemantic proximity Read ↗

Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytesSemantic proximity Read ↗

Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification.Semantic proximity Read ↗

L-Sox5 and Sox6 Proteins Enhance Chondrogenic miR-140 MicroRNA Expression by Strengthening Dimeric Sox9 ActivitySemantic proximity Read ↗

Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.Semantic proximity Read ↗

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