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Article

WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways.

The Journal of cell biology - 2 May 2011

Nalesso Giovanna, Sherwood Joanna, Bertrand Jessica, Pap Thomas, Ramachandran Manoj, De Bari Cosimo, Pitzalis Costantino, Dell'accio Francesco

Abstract excerpt

Activation and disruption of Wnt/β-catenin signaling both result in cartilage breakdown via unknown mechanisms. Here we show that both WNT-3A and the Wnt inhibitor DKK1 induced de-differentiation of human articular chondrocytes through simultaneous activation of β-catenin-dependent and independen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21536751
DOI: 10.1083/jcb.201011051
PMCID: PMC3087013

Genes

DKK1
AXIN2
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21536751-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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