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Article

The pro-osteogenic action of beta-catenin requires interaction with BMP signaling, but not Tcf/Lef transcriptional activity.

Journal of cellular biochemistry - 1 Jun 2008

Salazar Valerie S, Mbalaviele Gabriel, Civitelli Roberto

Abstract excerpt

The role of beta-catenin in skeletal development and osteogenic cell differentiation is well established, but the molecular mechanisms attending these effects remain largely unknown. We conducted a structure/function analysis of beta-catenin to gain further insights on these mechanisms. Retroviral transduction of a full-length, constitutively active beta-catenin mutant inhibited adipogenesis and stimulated...

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18247340
DOI: 10.1002/jcb.21679
PMCID: PMC3811910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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