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Article

Dual abnormal effects of mutant MITF encoded by Mi(wh) allele on mouse mast cells: decreased but recognizable transactivation and inhibition of transactivation.

Biochemical and biophysical research communications - 13 Sept 2002

Kataoka Tatsuki R, Morii Eiichi, Oboki Keisuke, Jippo Tomoko, Maeyama Kazutaka, Kitamura Yukihiko

Abstract excerpt

MITF is a basic helix-loop-helix leucine zipper-type transcription factor and is important for development of mast cells. MITF encoded by Mi(wh) allele (Mi(wh)-MITF) was mutated at a single amino acid of basic domain, and possessed a deficient but apparent DNA-binding ability. Here, we characterized the unique effects of Mi(wh)-MITF on the expression of mast cell-related genes. The expression level of mouse mast...

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Source

Identifiers

PMID: 12220516
DOI: 10.1016/s0006-291x(02)02131-9

Genes

MITF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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