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Article

Effects of G169R and P34S substitutions produced by mutations of CYP2D6*14 on the functional properties of CYP2D6 expressed in V79 cells.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2002

Shiraishi Tomoko, Hosokawa Masakiyo, Kobayashi Kaoru, Tainaka Hitoshi, Yamaura Yoshiyuki, Taguchi Miwo, Chiba Kan

Abstract excerpt

CYP2D6 is a polymorphic enzyme that catalyzes the oxidation of various drugs. At least 40-mutant alleles of CYP2D6 have been reported. CYP2D6*14, which is one of them found in Asian populations, causes deficient activity of CYP2D6. Four amino acid substitutions, P34S, G169R, R296C, and S486T, are present in the protein encoded by CYP2D6*14 (CYP2D6 14). Among them, G169R is thought to be a definitive substitution...

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Share to Cytochrome P-450 CYP2D6
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Identifiers

PMID: 12386125
DOI: 10.1124/dmd.30.11.1201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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