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Article

Comparison of substrate metabolism by wild type CYP2D6 protein and a variant containing methionine, not valine, at position 374.

Pharmacogenetics - 1 Aug 1995

Crespi C L, Steimel D T, Penman B W, Korzekwa K R, Fernandez-Salguero P, Buters J T, Gelboin H V, Gonzalez F J, Idle J R, Daly A K

Abstract excerpt

We have analysed kinetic parameters of cDNA-derived CYP2D6 proteins derived from the original CYP2D6 cDNA isolate (Gonzalez FJ et al. Nature 1988: 331, 442-446) which contains methionine at position 374 (CYP2D6-Met) and a modified cDNA which contains valine at position 374 (CYP2D6-Val). This latter protein is predicted from the CYP2D6 genomic sequence. Several quantitative differences, but no qualitative...

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PMID: 8528270
DOI: 10.1097/00008571-199508000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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