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Site-Directed Mutagenesis of Cytochrome P450 2D6 and 2C19 Enzymes: Expression and Spectral Characterization of Naturally Occurring Allelic Variants.

Applied biochemistry and biotechnology - 1 Sept 2018

Dong Amelia Nathania, Pan Yan, Palanisamy Uma Devi, Yiap Beow Chin, Ahemad Nafees, Ong Chin Eng

Abstract excerpt

Genetic polymorphism of the cytochrome P450 (CYP) genes particularly affects CYP2D6 and CYP2C19 to a functionally relevant extent, and it is therefore crucial to elucidate the enzyme kinetic and molecular basis for altered catalytic activity of these allelic variants. This study explored the expression and function of the reported alleles CYP2D6*2, CYP2D6*10, CYP2D6*17, CYP2C19*23, CYP2C19*24, and CYP2C19*25 with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29524040
DOI: 10.1007/s12010-018-2728-0

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