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Article

Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro.

Pharmacogenetics and genomics - 1 Nov 2010

Sandee Duanpen, Morrissey Kari, Agrawal Vishal, Tam Harrison K, Kramer Melissa A, Tracy Timothy S, Giacomini Kathleen M, Miller Walter L

Abstract excerpt

OBJECTIVES: Cytochrome P450 (P450) oxidoreductase (POR) donates electrons to all microsomal cytochrome P450s, including drug-metabolizing and steroidogenic enzymes. Severe POR mutations cause skeletal malformations and disordered steroidogenesis. The POR polymorphism A503V is found on approximately 28% of human alleles and decreases activities of CYP3A4 and steroidogenic CYP17, but not the activities of...

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Identifiers

PMID: 20940534
DOI: 10.1097/FPC.0b013e32833f4f9b
PMCID: PMC5708132

Genes

POR

Variants

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Source receipt: pubmed, retrieved 7 Sept 2026.

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