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Article

Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution.

Proteins - 1 May 2005

Allorge Delphine, Bréant Didier, Harlow Jacky, Chowdry Joey, Lo-Guidice Jean-Marc, Chevalier Dany, Cauffiez Christelle, Lhermitte Michel, Blaney Frank E, Tucker Geoffrey T, Broly Franck, Ellis S Wynne

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) is an important human drug-metabolizing enzyme that exhibits a marked genetic polymorphism. Numerous CYP2D6 alleles have been characterized at a functional level, although the consequences for expression and/or catalytic activity of a substantial number of rare variants remain to be investigated. One such allele, CYP2D6*31, is characterized by mutations encoding three amino acid...

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PMID: 15726636
DOI: 10.1002/prot.20399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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