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Article

Q172H replacement overcomes effects on the metabolism of cyclophosphamide and efavirenz caused by CYP2B6 variant with Arg262.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2011

Ariyoshi Noritaka, Ohara Miyuki, Kaneko Mayumi, Afuso Sakino, Kumamoto Takuya, Nakamura Hiroyoshi, Ishii Itsuko, Ishikawa Tsutomu, Kitada Mitsukazu

Abstract excerpt

There are a number of reports indicating that CYP2B6*6 (c.516G>T and c.785A>G) is responsible for decreased clearance of efavirenz (EFV), although increased disposition of cyclophosphamide (CPA) in individuals with this polymorphism was observed. Thus, we hypothesized that the effects of the two single nucleotide polymorphisms (SNPs) of CYP2B6*6 on the metabolism of drugs might be considerably different between...

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PMID: 21821736
DOI: 10.1124/dmd.111.039586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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