Article
Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-beta(2) gene.
Experimental nephrology - 1 Jan 2002
Pietri Laurence, Bloch-Faure May, Belair Marie-France, Sanford L Philip, Doetschman Tom, Ménard Joël, Bruneval Patrick, Meneton Pierre
Abstract excerpt
Transforming growth factors beta (TGF-betas) are peptides involved in autocrine and paracrine control of cell growth and differentiation. In the kidneys, TGF-beta(2) has been shown to localize specifically in renin-producing cells in various conditions stimulating the renin response. To test in vivo the functional role of TGF-beta(2), the renin response was investigated in mice heterozygous for a null mutation of...
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