Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genetically clamped renin transgene for the induction of hypertension.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2002

Caron Kathleen M I, James Leighton R, Kim Hyung-Suk, Morham Scott G, Sequeira Lopez Maria Luisa S, Gomez R Ariel, Reudelhuber Timothy L, Smithies Oliver

Abstract excerpt

Experimental analysis of the effects of individual components of complex mammalian systems is frequently impeded by compensatory adjustments that animals make to achieve homeostasis. We here introduce a genetic procedure for eliminating this type of impediment, by using as an example the development and testing of a transgene for "genetically clamping" the expression of renin, the major homeostatically responding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Weight
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Synthetic

Share to Hematocrit

Share to Hypertension

Share to Serum Albumin

Source

Open in PubMed Open full text

Identifiers

PMID: 12034874
DOI: 10.1073/pnas.112222199
PMCID: PMC123053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genetically clamped renin transgene for the induction of hypertension.PMID 12034874Read ↗

Lifelong genetic minipumps.Semantic proximity Read ↗

Blood pressure and renin-angiotensin system resetting in transgenic rats with elevated plasma Val5-angiotensinogen.Semantic proximity Read ↗

Physiological characterization of the hypertensive transgenic rat TGR(mREN2)27.Semantic proximity Read ↗

Gene targeting in physiological investigations: studies of the renin-angiotensin system.Semantic proximity Read ↗

A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation.Semantic proximity Read ↗

Transgenic mice as a tool to study the renin-angiotensin system.Semantic proximity Read ↗

Renin–angiotensin system research: from molecules to the whole bodySemantic proximity Read ↗

Hypertension, kidney, and transgenics: a fresh perspective.Semantic proximity Read ↗

Viral transduction of renin rapidly establishes persistent hypertension in diverse murine strains.Semantic proximity Read ↗

Controlled Hypertension, a Transgenic Toggle Switch Reveals Differential Mechanisms Underlying Vascular DiseaseSemantic proximity Read ↗

Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells.Semantic proximity Read ↗

Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgeneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.