Article
Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened.
Developmental cell - 1 May 2004
Sequeira López Maria Luisa S, Pentz Ellen S, Nomasa Takayo, Smithies Oliver, Gomez R Ariel
Abstract excerpt
Renin-synthesizing cells are crucial in the regulation of blood pressure and fluid-electrolyte homeostasis. Adult mammals subjected to manipulations that threaten homeostasis increase circulating renin by increasing the number of renin-expressing/-releasing cells. We hypothesize that the ability of adult cells to synthesize renin does not occur randomly in any cell type, depending instead on the cell's lineage....
Topics
- Animals
- Blood Pressure
- Cell Differentiation
- Cell Lineage
- Crosses, Genetic
- Epithelial Cells
- Genes, Reporter
- Glomerular Mesangium
- Homeostasis
- Juxtaglomerular Apparatus
- Mice