Article
Physiological characterization of the hypertensive transgenic rat TGR(mREN2)27.
The American journal of physiology - 1 Jun 1996
Lee M A, Böhm M, Paul M, Bader M, Ganten U, Ganten D
Abstract excerpt
Transgenic techniques represent powerful tools for the study of gene-related mechanisms of diseases such as hypertension, which results from a complex interaction between genetic and environmental factors. The renin-angiotensin system, a biochemical cascade in which renin functions as the key enzyme in the formation of the effector peptide angiotensin II, plays a major role in the regulation of blood pressure....
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