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Article

Angiotensin II-AT1-receptor signaling is necessary for cyclooxygenase-2-dependent postnatal nephron generation.

Kidney international - 1 Apr 2017

Frölich Stefanie, Slattery Patrick, Thomas Dominique, Goren Itamar, Ferreiros Nerea, Jensen Boye L, Nüsing Rolf M

Abstract excerpt

Deletion of cyclooxygenase-2 (COX-2) causes impairment of postnatal kidney development. Here we tested whether the renin angiotensin system contributes to COX-2-dependent nephrogenesis in mice after birth and whether a rescue of impaired renal development and function in COX-2-/- mice was achievable. Plasma renin concentration in mouse pups showed a birth peak and a second peak around day P8 during the first 10...

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PMID: 28040266
DOI: 10.1016/j.kint.2016.11.003

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