Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinically relevant endothelial nitric oxide synthase polymorphisms and their impact on drug response.

Expert opinion on drug metabolism & toxicology - 1 Oct 2020

Cotta Filho Cezar Kayzuka, Oliveira-Paula Gustavo Henrique, Rondon Pereira Vitória Carolina, Lacchini Riccardo

Abstract excerpt

INTRODUCTION: Nitric oxide (NO) is a molecule with multiple functions. Several drugs involve the modulation of NO levels in their mechanism of action. NO is mainly produced in vessels by endothelial NO synthase, which is encoded by NOS3 gene. This gene shows genetic polymorphisms associated with hypertension and other cardiovascular diseases, inflammation, psychiatric disorders, cancer, and others. AREAS COVERED:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nitric Oxide

Share to Nitric Oxide Synthase Type III

Share to Pharmaceutical Preparations

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 32746648
DOI: 10.1080/17425255.2020.1804857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinically relevant endothelial nitric oxide synthase polymorphisms and their impact on drug response.PMID 32746648Read ↗

Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms.Semantic proximity Read ↗

Human Nitric Oxide Synthase-Its Functions, Polymorphisms, and Inhibitors in the Context of Inflammation, Diabetes and Cardiovascular Diseases.Semantic proximity Read ↗

Therapeutic implications of human endothelial nitric oxide synthase gene polymorphism.Semantic proximity Read ↗

Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review.Semantic proximity Read ↗

Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseasesSemantic proximity Read ↗

Endothelial nitric oxide synthase gene polymorphisms in cardiovascular disease.Semantic proximity Read ↗

Association Patterns of Endothelial Nitric Oxide Synthase Gene (NOS3) Variant Glu298Asp with Blood Pressure and Serum Lipid Levels in Subjects with Coronary Artery Disease from Pakistan.Semantic proximity Read ↗

Contribution of NOS3AS Variants to Susceptibility to Essential Hypertension: A Study in Kermanshah Province, Western Iran.Semantic proximity Read ↗

Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias.Semantic proximity Read ↗

Genetic Factors of Nitric Oxide’s System in Psychoneurologic DisordersSemantic proximity Read ↗

Endothelial nitric oxide synthase gene: prospects for treatment of heart disease.Semantic proximity Read ↗

Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.