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Article

Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms.

Gene - 10 Jan 2016

Oliveira-Paula Gustavo H, Lacchini Riccardo, Tanus-Santos Jose E

Abstract excerpt

Nitric oxide (NO) is an important vasodilator with a well-established role in cardiovascular homeostasis. While mediator is synthesized from L-arginine by neuronal, endothelial, and inducible nitric oxide synthases (NOS1,NOS3 and NOS2 respectively), NOS3 is the most important isoform for NO formation in the cardiovascular system. NOS3 is a dimeric enzyme whose expression and activity are regulated at...

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Share to Cardiovascular System
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NOS1 gene

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Share to Genetic Predisposition to Disease

Share to Nitric Oxide

Share to Nitric Oxide Synthase Type III

Share to Polymorphism, Genetic

Source

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Identifiers

PMID: 26428312
DOI: 10.1016/j.gene.2015.09.061
PMCID: PMC6728140

Genes

NOS3
NOS1
NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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