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Article

Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin.

The Journal of cell biology - 30 Sept 2002

Dou Yali, Bowen Josephine, Liu Yifan, Gorovsky Martin A

Abstract excerpt

In Tetrahymena cells, phosphorylation of linker histone H1 regulates transcription of specific genes. Phosphorylation acts by creating a localized negative charge patch and phenocopies the loss of H1 from chromatin, suggesting that it affects transcription by regulating the dissociation of H1 from chromatin. To test this hypothesis, we used FRAP of GFP-tagged H1 to analyze the effects of mutations that either...

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Identifiers

PMID: 12356861
DOI: 10.1083/jcb.200202131
PMCID: PMC2173238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin.PMID 12356861Read ↗

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