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Article

Phosphorylation of heterochromatin protein 1 by casein kinase II is required for efficient heterochromatin binding in Drosophila.

The Journal of biological chemistry - 21 May 1999

Zhao T, Eissenberg J C

Abstract excerpt

Heterochromatin-associated protein 1 (HP1) is a nonhistone chromosomal protein with a dose-dependent effect on heterochromatin mediated position-effect silencing. It is multiply phosphorylated in vivo. Hyperphosphorylation of HP1 is correlated with heterochromatin assembly. We report here that HP1 is phosphorylated by casein kinase II in vivo at three serine residues located at the N and C termini of the protein....

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Source

Identifiers

PMID: 10329715
DOI: 10.1074/jbc.274.21.15095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation of heterochromatin protein 1 by casein kinase II is required for efficient heterochromatin binding in Drosophila.PMID 10329715Read ↗

Mutations in the heterochromatin protein 1 (HP1) hinge domain affect HP1 protein interactions and chromosomal distribution.Semantic proximity Read ↗

Distinct cytoplasmic and nuclear fractions of Drosophila heterochromatin protein 1: their phosphorylation levels and associations with origin recognition complex proteins.Semantic proximity Read ↗

Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation.Semantic proximity Read ↗

A heat shock-activated cDNA rescues the recessive lethality of mutations in the heterochromatin-associated protein HP1 of Drosophila melanogaster.Semantic proximity Read ↗

The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.Semantic proximity Read ↗

Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite Plasmodium falciparum.Semantic proximity Read ↗

Heterochromatin protein 1 is recruited to various types of DNA damage.Semantic proximity Read ↗

Interaction of heterochromatin protein 2 with HP1 defines a novel HP1-binding domain.Semantic proximity Read ↗

N-terminal phosphorylation of HP1{alpha} promotes its chromatin binding.Semantic proximity Read ↗

Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing.Semantic proximity Read ↗

A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response.Semantic proximity Read ↗

Protein phosphorylation is involved in the regulation of chromatin condensation during interphase.Semantic proximity Read ↗

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