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Article

ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding.

Open biology - 1 Dec 2014

Akai Yuko, Kanai Ryuta, Nakazawa Norihiko, Ebe Masahiro, Toyoshima Chikashi, Yanagida Mitsuhiro

Abstract excerpt

Condensin, which contains two structural maintenance of chromosome (SMC) subunits and three regulatory non-SMC subunits, is essential for many chromosomal functions, including mitotic chromosome condensation and segregation. The ATPase domain of the SMC subunit comprises two termini connected by a long helical domain that is interrupted by a central hinge. The role of the ATPase domain has remained elusive. Here...

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Identifiers

PMID: 25520186
DOI: 10.1098/rsob.140193
PMCID: PMC4281712

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Source receipt: pubmed, retrieved 7 Sept 2026.

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