Article
ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding.
Open biology - 1 Dec 2014
Akai Yuko, Kanai Ryuta, Nakazawa Norihiko, Ebe Masahiro, Toyoshima Chikashi, Yanagida Mitsuhiro
Abstract excerpt
Condensin, which contains two structural maintenance of chromosome (SMC) subunits and three regulatory non-SMC subunits, is essential for many chromosomal functions, including mitotic chromosome condensation and segregation. The ATPase domain of the SMC subunit comprises two termini connected by a long helical domain that is interrupted by a central hinge. The role of the ATPase domain has remained elusive. Here...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Catalytic Domain
- Chromosomal Proteins, Non-Histone
- Conserved Sequence
- DNA, Fungal
- DNA-Binding Proteins
- Models, Molecular
- Multiprotein Complexes
- Mutation