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Article

Regulation of transcription by H1 phosphorylation in Tetrahymena is position independent and requires clustered sites.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002

Dou Yali, Gorovsky Martin A

Abstract excerpt

In Tetrahymena cells, constitutive phosphorylation of histone H1 phenocopies the loss of H1 from chromatin. Regulation of transcription by H1 phosphorylation is achieved by altering the overall charges of a small domain. Here, we further explore the electrostatic properties of this domain and the mechanism by which it regulates transcription. We demonstrate that the regulatory effect of the clustered charges does...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11972045
DOI: 10.1073/pnas.092029599
PMCID: PMC122916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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