Article
RETRACTED: TAF1 activates transcription by phosphorylation of serine 33 in histone H2B.
Science (New York, N.Y.) - 14 May 2004
Maile Tobias, Kwoczynski Simona, Katzenberger Rebeccah J, Wassarman David A, Sauer Frank
Abstract excerpt
Dynamic changes in chromatin structure, induced by posttranslational modification of histones, play a fundamental role in regulating eukaryotic transcription. Here we report that histone H2B is phosphorylated at evolutionarily conserved Ser33 (H2B-S33) by the carboxyl-terminal kinase domain (CTK) of the Drosophila TFIID subunit TAF1. Phosphorylation of H2B-S33 at the promoter of the cell cycle regulatory gene...
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