Article
RETRACTED: TAF1 activates transcription by phosphorylation of serine 33 in histone H2B.
Science (New York, N.Y.) - 14 May 2004
Maile Tobias, Kwoczynski Simona, Katzenberger Rebeccah J, Wassarman David A, Sauer Frank
Abstract excerpt
Dynamic changes in chromatin structure, induced by posttranslational modification of histones, play a fundamental role in regulating eukaryotic transcription. Here we report that histone H2B is phosphorylated at evolutionarily conserved Ser33 (H2B-S33) by the carboxyl-terminal kinase domain (CTK) of the Drosophila TFIID subunit TAF1. Phosphorylation of H2B-S33 at the promoter of the cell cycle regulatory gene...
Topics
- Acetylation
- Amino Acid Motifs
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Cell Cycle
- Cell Cycle Proteins
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Embryo, Nonmammalian
- Genes, Insect
- Histone Acetyltransferases