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Article

The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo.

The Journal of biological chemistry - 7 May 2004

Hendzel Michael J, Lever Melody A, Crawford Ellen, Th'ng John P H

Abstract excerpt

We have used a combination of kinetic measurements and targeted mutations to show that the C-terminal domain is required for high-affinity binding of histone H1 to chromatin, and phosphorylations can disrupt binding by affecting the secondary structure of the C terminus. By measuring the fluoresc...

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PMID: 14985337
DOI: 10.1074/jbc.M400070200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14985337-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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