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Article

Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics.

Journal of neurochemistry - 1 Sept 2002

Miksys Sharon, Rao Yushu, Hoffmann Ewa, Mash Deborah C, Tyndale Rachel F

Abstract excerpt

Cytochrome P450 (CYP) 2D6 is expressed in liver, brain and other extrahepatic tissues where it metabolizes a range of centrally acting drugs and toxins. As ethanol can induce CYP2D in rat brain, we hypothesized that CYP2D6 expression is higher in brains of human alcoholics. We examined regional and cellular expression of CYP2D6 mRNA and protein by RT-PCR, Southern blotting, slot blotting, immunoblotting and...

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Source

Identifiers

PMID: 12354285
DOI: 10.1046/j.1471-4159.2002.01069.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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