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Article

Potential role of CYP2D6 in the central nervous system.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Nov 2013

Cheng Jie, Zhen Yueying, Miksys Sharon, Beyoğlu Diren, Krausz Kristopher W, Tyndale Rachel F, Yu Aiming, Idle Jeffrey R, Gonzalez Frank J

Abstract excerpt

1. Cytochrome P450 2D6 (CYP2D6) is a pivotal enzyme responsible for a major drug oxidation polymorphism in human populations. Distribution of CYP2D6 in brain and its role in serotonin metabolism suggest that CYP2D6 may have a function in the central nervous system. 2. To establish an efficient and accurate platform for the study of CYP2D6 in vivo, a human CYP2D6 (Tg-2D6) model was generated by transgenesis in...

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Identifiers

PMID: 23614566
DOI: 10.3109/00498254.2013.791410
PMCID: PMC3750078

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