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Article

CYP2D6 in the brain: genotype effects on resting brain perfusion.

Molecular psychiatry - 1 Mar 2011

Kirchheiner J, Seeringer A, Godoy A L, Ohmle B, Maier C, Beschoner P, Sim E-J, Viviani R

Abstract excerpt

The cytochrome P450 2D6 (CYP2D6) is a genetically polymorphic enzyme involved in the metabolism of several psychoactive drugs. Beside its expression in the liver, CYP2D6 is highly expressed in several regions of the brain, such as the hippocampus, thalamus, hypothalamus and the cortex, but its function in the brain is not well understood. The CYP2D6 enzyme may also have a physiological role due to its involvement...

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Identifiers

PMID: 20368706
DOI: 10.1038/mp.2010.42

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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