Article
Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jan 2015
Toselli Francesca, de Waziers Isabelle, Dutheil Mary, Vincent Marc, Wilce Peter A, Dodd Peter R, Beaune Philippe, Loriot Marie-Anne, Gillam Elizabeth M J
Abstract excerpt
1. Ethanol consumption and smoking alter the expression of certain drug-metabolizing enzymes and transporters, potentially influencing the tissue-specific effects of xenobiotics. 2. Amygdala (AMG) and prefrontal cortex (PFC) are brain regions that modulate the effects of alcohol and smoking, yet little is known about the expression of cytochrome P450 enzymes (P450s) and ATP-binding cassette (ABC) transporters in...
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