Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain.

Pharmacogenetics - 1 Apr 2001

Siegle I, Fritz P, Eckhardt K, Zanger U M, Eichelbaum M

Abstract excerpt

The cytochrome P4502D6 (CYP2D6) is involved in the biotransformation of many drugs which predominantly act in the central nervous system (CNS), including opioids, various psychotrophic drugs and neurotoxins. Until now, however, only controversial information is available regarding the presence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to COS Cells
Share to Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to In Situ Hybridization

Share to RNA, Messenger

Share to RNA Probes

Share to Transfection

Source

Identifiers

PMID: 11337939
DOI: 10.1097/00008571-200104000-00007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11337939-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain.PMID 11337939Read ↗

Regional and cellular distribution of CYP2D subfamily members in rat brainSemantic proximity Read ↗

Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics.Semantic proximity Read ↗

Potential role of CYP2D6 in the central nervous system.Semantic proximity Read ↗

Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain.Semantic proximity Read ↗

The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients.Semantic proximity Read ↗

The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.Semantic proximity Read ↗

Selective localisation of P450 enzymes and NADPH-P450 oxidoreductase in rat basal ganglia using anti-peptide antisera.Semantic proximity Read ↗

mRNA distribution and heterologous expression of orphan cytochrome P450 20A1.Semantic proximity Read ↗

Anatomical distribution and expression of CYP in humans: Neuropharmacological implicationsSemantic proximity Read ↗

Constitutive expression and localization of cytochrome P-450 1A1 in rat and human brain: presence of a splice variant form in human brain.Semantic proximity Read ↗

Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: The convolution continues.Semantic proximity Read ↗

Evaluation of CYP2D6 Protein Expression and Activity in the Small Intestine to Determine Its Metabolic Capability in the Japanese Population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.