Drug-metabolizing cytochrome P450s in the brain

Abstract excerpt

Most CYP subfamilies have been identified in brain, but there is much more information available on the distribution and metabolic activity of CYP subfamilies in brain of rodents than in humans, and what we do know still lags far behind our knowledge of hepatic CYPs. With the constant acquisition of data on the genetics, molecular structure and metabolic capacity of brain CYPs, we are increasingly able to...

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