The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients.

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) is a drug-metabolizing enzyme expressed in the brain that also metabolizes endogenous neural compounds (e.g., catecholamines) and inactivates neurotoxins (e.g., 1-methyl-4-thenyl-1,2,3,6-tetrahydropyridine; MPTP). Genetically poor CYP2D6 metabolizers are at higher risk for developing Parkinson's disease (PD), a risk that increases with exposure to pesticides. As age is a risk factor...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Age Factors
• Share to Brain
• Share to Cytochrome P-450 CYP2D6