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Article

Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain.

Neuropharmacology - 1 Jul 2003

Miksys Sharon, Lerman Caryn, Shields Peter G, Mash Deborah C, Tyndale Rachel F

Abstract excerpt

CYP2B6 metabolizes drugs such as nicotine and bupropion, and many toxins and carcinogens. Nicotine induces CYP2B1 in rat brain and in humans polymorphic variation in CYP2B6 affects smoking cessation rates. The aim of this study was to compare CYP2B6 expression in brains of human smokers and non-smokers and alcoholics and non-alcoholics (n=26). CYP2B6 expression was brain region-specific, and was observed in both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oxidoreductases, N-Demethylating

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Source

Identifiers

PMID: 12814665
DOI: 10.1016/s0028-3908(03)00136-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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