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Article

Regional and cellular distribution of CYP2D subfamily members in rat brain

1 Jan 2000

Abstract excerpt

1. Human CYP2D6 is present in brain, metabolizes many drugs and has been implicated in Parkinson's and Alzheimer's diseases and some cancers. It is still unclear which of the six known rat CYP2D subfamily members is/are homologous to human CYP2D6. 2. In this study, RT-PCR, Southern and Western blotting and immunohistochemical techniques were used to study the distribution of CYP2D subfamily member mRNA and...

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PMID: 10923858
DOI: 10.1080/004982500406390

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