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Article

High incidence of protein-truncating mutations of the p53 gene in liver metastases of colorectal carcinomas.

Oncogene - 26 Sept 2002

Miyaki Michiko, Iijima Takeru, Yasuno Masamichi, Kita Yumi, Hishima Tsunekazu, Kuroki Toshio, Mori Takeo

Abstract excerpt

To clarify the significance of p53 mutations in liver metastasis of colorectal carcinogenesis, the characteristics of p53 mutations from 51 liver metastases and 76 primary invasive carcinomas without liver metastasis (Dukes' A, B and C) were compared. The frequency of tumors with p53 mutations was 61% (31 out of 51) in the liver metastases, and 51% (39 out of 76) in the primary carcinomas without liver...

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Identifiers

PMID: 12242668
DOI: 10.1038/sj.onc.1205887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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