Article
Mutations in TP53 are a prognostic factor in colorectal hepatic metastases undergoing surgical resection.
Carcinogenesis - 1 Jun 2007
Molleví David G, Serrano Teresa, Ginestà Mireia M, Valls Joan, Torras Jaume, Navarro Matilde, Ramos Emilio, Germà Josep R, Jaurrieta Eduardo, Moreno Víctor, Figueras Joan, Capellà Gabriel, Villanueva Alberto
Abstract excerpt
The aim of this study was to analyze the prognostic value of TP53 mutations in a consecutive series of patients with hepatic metastases (HMs) from colorectal cancer undergoing surgical resection. Ninety-one patients with liver metastases from colorectal carcinoma were included. Mutational analysis of TP53, exons 4-10, was performed by single-strand conformation polymorphism and sequencing. P53 and P21 protein...
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