[p53 mutations and protein overexpression in primary colorectal cancer and its liver metastasis].

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

[p53 mutations and protein overexpression in primary colorectal cancer and its liver metastasis].

Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Mar 1999

Yang Y, Xia Q, Lian F

Abstract excerpt

OBJECTIVE: To compare p53 status between primary and hepatic metastatic colorectal cancer in 34 patients. METHODS: p53 gene status (exon 5-9) was examined by PCR, denaturing gradient gel electrophoresis (DGGE) and automated sequencing. p53 protein was detected by immunohistochemistry using monoclonal antibody DO-7. RESULTS: p53 mutations were found in exons 5 through 9 in 21 of 34 patients (61.8%). Among them, 5...

Topics

Colorectal Neoplasms
Genes, p53
Humans
Immunohistochemistry
Liver Neoplasms
Mutation
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 11776850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics