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Article

Identification of a role for actin in translational fidelity in yeast.

Molecular genetics and genomics : MGG - 1 Sept 2002

Kandl K A, Munshi R, Ortiz P A, Andersen G R, Kinzy T G, Adams A E M

Abstract excerpt

Numerous studies have suggested a role for actin in translation, but the molecular details of this role are unknown. To elucidate the function(s) of actin in translation, we have studied 25 isogenic, conditional yeast actin mutants. Strikingly, analysis of these mutants indicates that none of those tested have conditional growth defects caused by reduced rates of protein synthesis; and analysis of latrunculin...

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Source

Identifiers

PMID: 12242494
DOI: 10.1007/s00438-002-0726-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a role for actin in translational fidelity in yeast.PMID 12242494Read ↗

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Translation elongation factor 1A is essential for regulation of the actin cytoskeleton and cell morphology.Semantic proximity Read ↗

Loss of translational control in yeast compromised for the major mRNA decay pathway.Semantic proximity Read ↗

Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast.Semantic proximity Read ↗

SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation.Semantic proximity Read ↗

Mosaic changes to the global transcriptome in response to inhibiting ribosome formation versus inhibition of ribosome functionSemantic proximity Read ↗

Translation elongation factor 1A mutants with altered actin bundling activity show reduced aminoacyl-tRNA binding and alter initiation via eIF2α phosphorylation.Semantic proximity Read ↗

Mutations in yeast ribosomal proteins S28 and S4 affect the accuracy of translation and alter the sensitivity of the ribosomes to paromomycin.Semantic proximity Read ↗

Mutations in eukaryotic 18S ribosomal RNA affect translational fidelity and resistance to aminoglycoside antibiotics.Semantic proximity Read ↗

A single amino acid substitution in yeast eIF-5A results in mRNA stabilization.Semantic proximity Read ↗

The Mof2/Sui1 protein is a general monitor of translational accuracy.Semantic proximity Read ↗

A ribosomal protein is required for translational regulation of GCN4 mRNA. Evidence for involvement of the ribosome in eIF2 recycling.Semantic proximity Read ↗

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