SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation.

doi:10.1016/s0092-8674(05)80012-1

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Article

SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation.

Cell - 30 Jun 1995

Ogg S C, Walter P

Abstract excerpt

The signal recognition particle (SRP) binds to ribosomes that synthesize nascent chains bearing signal sequences and catalyzes their targeting to the endoplasmic reticulum membrane. In S. cerevisiae, a temperature-sensitive mutation in the SEC65 gene, encoding an SRP subunit, results in lowered levels of SRP. Growth and protein translocation defects induced by this mutation can be suppressed specifically by...

Topics

Animals
Cycloheximide
Endoplasmic Reticulum
Fungal Proteins
Genes, Fungal
Genotype
Kinetics
Macromolecular Substances
Mammals
Mutagenesis
Peptide Chain Elongation, Translational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Biosynthesis

Protein Processing, Post-Translational

Protein Synthesis Inhibitors

Ribosomes

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Signal Recognition Particle

Source

Open in PubMed

Identifiers

PMID: 7600575
DOI: 10.1016/s0092-8674(05)80012-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7600575-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation.PMID 7600575Read ↗

Elongation arrest is a physiologically important function of signal recognition particle.Semantic proximity Read ↗

Continued functioning of the secretory pathway is essential for ribosome synthesis.Semantic proximity Read ↗

The signal recognition particle in S. cerevisiae.Semantic proximity Read ↗

Access to ribosomal protein Rpl25p by the signal recognition particle is required for efficient cotranslational translocation.Semantic proximity Read ↗

A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae.Semantic proximity Read ↗

40S ribosomal subunits scan mRNA for the start codon by one-dimensional diffusion.Semantic proximity Read ↗

Distant segments of Saccharomyces cerevisiae scR1 RNA promote assembly and function of the signal recognition particle.Semantic proximity Read ↗

Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.Semantic proximity Read ↗

The large ribosomal subunit protein L9 enables the growth of EF-P deficient cells and enhances small subunit maturation.Semantic proximity Read ↗

Multifaceted physiological response allows yeast to adapt to the loss of the signal recognition particle-dependent protein-targeting pathway.Semantic proximity Read ↗

A membrane transport defect leads to a rapid attenuation of translation initiation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Immature large ribosomal subunits containing the 7S pre-rRNA can engage in translation in Saccharomyces cerevisiae.Semantic proximity Read ↗

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