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Article

Mutations in eukaryotic 18S ribosomal RNA affect translational fidelity and resistance to aminoglycoside antibiotics.

The EMBO journal - 15 Feb 1994

Chernoff Y O, Vincent A, Liebman S W

Abstract excerpt

Mutations have been created in the Saccharomyces cerevisiae 18S rRNA gene that correspond to those known to be involved in the control of translational fidelity or antibiotic resistance in prokaryotes. Yeast strains, in which essentially all chromosomal rDNA repeats are deleted and all cellular rRNAs are encoded by plasmid, have been constructed that contain only mutant 18S rRNA. In Escherichia coli, a C-->U...

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Identifiers

PMID: 8112304
DOI: 10.1002/j.1460-2075.1994.tb06334.x
PMCID: PMC394890

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Mutations in eukaryotic 18S ribosomal RNA affect translational fidelity and resistance to aminoglycoside antibiotics.PMID 8112304Read ↗

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