Mutations in eukaryotic 18S ribosomal RNA affect translational fidelity and resistance to aminoglycoside antibiotics.

doi:10.1002/j.1460-2075.1994.tb06334.x

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Article

Mutations in eukaryotic 18S ribosomal RNA affect translational fidelity and resistance to aminoglycoside antibiotics.

The EMBO journal - 15 Feb 1994

Chernoff Y O, Vincent A, Liebman S W

Abstract excerpt

Mutations have been created in the Saccharomyces cerevisiae 18S rRNA gene that correspond to those known to be involved in the control of translational fidelity or antibiotic resistance in prokaryotes. Yeast strains, in which essentially all chromosomal rDNA repeats are deleted and all cellular r...

Topics

Base Sequence
DNA, Ribosomal
Drug Resistance, Microbial
Escherichia coli
Genes, Dominant
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Phenotype
Protein Biosynthesis
RNA, Ribosomal, 18S
Saccharomyces cerevisiae
Streptomycin

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