Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A single amino acid substitution in yeast eIF-5A results in mRNA stabilization.

The EMBO journal - 15 May 1998

Zuk D, Jacobson A

Abstract excerpt

Most factors known to function in mRNA turnover are not essential for cell viability. To identify essential factors, approximately 4000 temperature-sensitive yeast strains were screened for an increase in the level of the unstable CYH2 pre-mRNA. At the non-permissive temperature, five mutants exhibited decreased decay rates of the CYH2 pre-mRNA and mRNA, and the STE2, URA5 and PAB1 mRNAs. Of these, the mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fungal Proteins

Share to Genes, Fungal

Share to Molecular Sequence Data

Share to Mutagenesis

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 9582285
DOI: 10.1093/emboj/17.10.2914
PMCID: PMC1170632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single amino acid substitution in yeast eIF-5A results in mRNA stabilization.PMID 9582285Read ↗

A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae.Semantic proximity Read ↗

Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathway.Semantic proximity Read ↗

eIF5A is an indispensable protein for eukaryotic cellsSemantic proximity Read ↗

Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling.Semantic proximity Read ↗

Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Eukaryotic translation initiation factor 5 is critical for integrity of the scanning preinitiation complex and accurate control of GCN4 translation.Semantic proximity Read ↗

Rapid depletion of mutant eukaryotic initiation factor 5A at restrictive temperature reveals connections to actin cytoskeleton and cell cycle progression.Semantic proximity Read ↗

eIF5A is an indispensable protein for eukaryotic cellsSemantic proximity Read ↗

Isolation and functional characterization of a temperature-sensitive mutant of the yeast Saccharomyces cerevisiae in translation initiation factor eIF5: an eIF5-dependent cell-free translation system.Semantic proximity Read ↗

An internal open reading frame triggers nonsense-mediated decay of the yeast SPT10 mRNA.Semantic proximity Read ↗

Temperature-sensitive mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 genes result in defects in mRNA turnover.Semantic proximity Read ↗

Stm1 modulates mRNA decay and Dhh1 function in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.