Article
A ribosomal protein is required for translational regulation of GCN4 mRNA. Evidence for involvement of the ribosome in eIF2 recycling.
The Journal of biological chemistry - 4 Dec 1998
Mueller P P, Grueter P, Hinnebusch A G, Trachsel H
Abstract excerpt
In amino acid-starved yeast cells, inhibition of the guanine nucleotide exchange factor eIF2B by phosphorylated translation initiation factor 2 results in increased translation of GCN4 mRNA. We isolated a suppressor of a mutant eIF2B. The suppressor prevents efficient GCN4 mRNA translation due to...
Topics
- Alleles
- Base Sequence
- DNA Primers
- DNA-Binding Proteins
- Eukaryotic Initiation Factor-2B
- Fungal Proteins
- Guanine Nucleotide Exchange Factors
- Mutation
- Protein Biosynthesis
- Protein Kinases
- Proteins
- RNA, Messenger
- Ribosomal Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins