Article
Loss of translational control in yeast compromised for the major mRNA decay pathway.
Molecular and cellular biology - 1 Apr 2004
Holmes L E A, Campbell S G, De Long S K, Sachs A B, Ashe M P
Abstract excerpt
The cytoplasmic fate of mRNAs is dictated by the relative activities of the intimately connected mRNA decay and translation initiation pathways. In this study, we have found that yeast strains compromised for stages downstream of deadenylation in the major mRNA decay pathway are incapable of inhibiting global translation initiation in response to stress. In the past, the paradigm of the eIF2alpha kinase-dependent...
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