Article

Mosaic changes to the global transcriptome in response to inhibiting ribosome formation versus inhibition of ribosome function

2020-10-15

Abstract excerpt

Cell fate is susceptible to several internal and external stresses. Stress resulting from mutations in genes for ribosomal proteins and assembly factors leads to many congenital diseases, collectively called ribosomopathies. Even though such mutations all depress the cell’s protein synthesis capacity, they are manifested in many different phenotypes. This prompted us to use Saccharomyces cerevisiae to explore whe...

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Literature Corpus work: f63268b4-e9d9-5701-9c4e-8db1a99f95b8
DOI: 10.1101/2020.10.15.341230

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