Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat.

doi:10.1042/bj3010001

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat.

The Biochemical journal - 1 Jul 1994

Yamaguchi Y, Heiny M E, Shimizu N, Aoki T, Gitlin J D

Abstract excerpt

Long-Evans Cinnamon rats develop a necrotizing hepatitis characterized by excessive hepatic copper accumulation, defective holoceruloplasmin biosynthesis and impaired biliary copper excretion. To elucidate the molecular basis of this defect, a cDNA clone encoding the rat Wilson disease gene was isolated and used to examine gene expression in selected tissues from normal and Long-Evans Cinnamon rats. Although this...

Topics

Adenosine Triphosphatases
Amino Acid Sequence
Animals
Base Sequence
Cation Transport Proteins
Copper
Copper-Transporting ATPases
DNA, Complementary
Gene Expression
Hepatolenticular Degeneration
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Menkes Kinky Hair Syndrome

Molecular Sequence Data

Mutation

Rats

Rats, Mutant Strains

Sequence Homology, Amino Acid

Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 8037655
DOI: 10.1042/bj3010001
PMCID: PMC1137132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8037655-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat.PMID 8037655Read ↗

Decreased expression of liver glutathione peroxidase in Long-Evans cinnamon mutant rats predisposed to hepatitis and hepatoma.Semantic proximity Read ↗

The rat homologue of the Wilson's disease gene was partially deleted at the 3' end of its protein-coding region in Long-Evans Cinnamon mutant rats.Semantic proximity Read ↗

Demonstrating Potential of Cell Therapy for Wilson's Disease with the Long-Evans Cinnamon Rat Model.Semantic proximity Read ↗

Isolation and Characterization of a Human Liver cDNA as a Candidate Gene for Wilson DiseaseSemantic proximity Read ↗

Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats.Semantic proximity Read ↗

DNA damage triggers imbalance of proliferation and apoptosis during development of preneoplastic foci in the liver of Long-Evans Cinnamon rats.Semantic proximity Read ↗

Hepatocyte transplantation in the Long Evans Cinnamon rat model of Wilson's disease.Semantic proximity Read ↗

Increased mutant frequency and altered mutation spectrum of the lacI transgene in Wilson disease rats with hepatitis.Semantic proximity Read ↗

Abnormal ethanol metabolism in Long-Evans Cinnamon rats, a mutant strain developing spontaneous hepatoma.Semantic proximity Read ↗

Role of hepatic copper-metallothionein on liver function of Long-Evans cinnamon rats with a new mutation causing hereditary hepatitis.Semantic proximity Read ↗

Genomic DNA analyses of spontaneous hepatocellular carcinomas in LEC rat liver using a new technique.Semantic proximity Read ↗

Correlation between a hepatic copper accumulation and an altered expression of glutathione S-transferase Ya/Yc subunits in LEC mutant rat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.