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Article

Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat.

The Biochemical journal - 1 Jul 1994

Yamaguchi Y, Heiny M E, Shimizu N, Aoki T, Gitlin J D

Abstract excerpt

Long-Evans Cinnamon rats develop a necrotizing hepatitis characterized by excessive hepatic copper accumulation, defective holoceruloplasmin biosynthesis and impaired biliary copper excretion. To elucidate the molecular basis of this defect, a cDNA clone encoding the rat Wilson disease gene was isolated and used to examine gene expression in selected tissues from normal and Long-Evans Cinnamon rats. Although this...

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Identifiers

PMID: 8037655
DOI: 10.1042/bj3010001
PMCID: PMC1137132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat.PMID 8037655Read ↗

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Demonstrating Potential of Cell Therapy for Wilson's Disease with the Long-Evans Cinnamon Rat Model.Semantic proximity Read ↗

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DNA damage triggers imbalance of proliferation and apoptosis during development of preneoplastic foci in the liver of Long-Evans Cinnamon rats.Semantic proximity Read ↗

Hepatocyte transplantation in the Long Evans Cinnamon rat model of Wilson's disease.Semantic proximity Read ↗

Increased mutant frequency and altered mutation spectrum of the lacI transgene in Wilson disease rats with hepatitis.Semantic proximity Read ↗

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Role of hepatic copper-metallothionein on liver function of Long-Evans cinnamon rats with a new mutation causing hereditary hepatitis.Semantic proximity Read ↗

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