Article
Abnormal ethanol metabolism in Long-Evans Cinnamon rats, a mutant strain developing spontaneous hepatoma.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement - 1 Jan 1993
Nakajima M, Kato J, Kohgo Y, Katsuki S, Inui N, Ohya M, Takeichi N, Niitu Y
Abstract excerpt
The Long-Evans Cinnamon (LEC) rat is a mutant strain established from Long-Evans rats. LEC rats display hereditary hepatitis and spontaneous hepatocellular carcinoma (HCC). We first tried to examine effects of ethanol consumption on the development of HCC, and fed a Lieber's liquid diet containin...
Topics
- Acetaldehyde
- Alcohol Dehydrogenase
- Alcoholism
- Aldehyde Dehydrogenase
- Animals
- Cell Transformation, Neoplastic
- Ethanol
- Genotype
- Liver
- Liver Neoplasms, Experimental
- Male
- Mutation
- Rats
- Rats, Inbred Strains