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Article

Abnormal ethanol metabolism in Long-Evans Cinnamon rats, a mutant strain developing spontaneous hepatoma.

Alcohol and alcoholism (Oxford, Oxfordshire). Supplement - 1 Jan 1993

Nakajima M, Kato J, Kohgo Y, Katsuki S, Inui N, Ohya M, Takeichi N, Niitu Y

Abstract excerpt

The Long-Evans Cinnamon (LEC) rat is a mutant strain established from Long-Evans rats. LEC rats display hereditary hepatitis and spontaneous hepatocellular carcinoma (HCC). We first tried to examine effects of ethanol consumption on the development of HCC, and fed a Lieber's liquid diet containing 5% ethanol to LEC rats. However the rats died within 2 weeks because of acute alcohol intoxication. In LEC rats, the...

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PMID: 8003122
DOI: 10.1093/alcalc/28.supplement_1b.105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Abnormal ethanol metabolism in Long-Evans Cinnamon rats, a mutant strain developing spontaneous hepatoma.PMID 8003122Read ↗

Role of hepatic copper-metallothionein on liver function of Long-Evans cinnamon rats with a new mutation causing hereditary hepatitis.Semantic proximity Read ↗

DNA damage triggers imbalance of proliferation and apoptosis during development of preneoplastic foci in the liver of Long-Evans Cinnamon rats.Semantic proximity Read ↗

Decreased expression of liver glutathione peroxidase in Long-Evans cinnamon mutant rats predisposed to hepatitis and hepatoma.Semantic proximity Read ↗

Biochemical polymorphisms in Long-Evans Cinnamon (LEC) inbred strain of rat.Semantic proximity Read ↗

Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat.Semantic proximity Read ↗

Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats.Semantic proximity Read ↗

Genomic DNA analyses of spontaneous hepatocellular carcinomas in LEC rat liver using a new technique.Semantic proximity Read ↗

Phenotype of preneoplastic and neoplastic liver lesions during spontaneous liver carcinogenesis of LEC rats.Semantic proximity Read ↗

New mutation causing hereditary hepatitis in the laboratory rat.Semantic proximity Read ↗

Correlation between a hepatic copper accumulation and an altered expression of glutathione S-transferase Ya/Yc subunits in LEC mutant rat.Semantic proximity Read ↗

Increased polyploid incidence is associated with abnormal copper accumulation in the liver of LEC mutant rat.Semantic proximity Read ↗

The rat homologue of the Wilson's disease gene was partially deleted at the 3' end of its protein-coding region in Long-Evans Cinnamon mutant rats.Semantic proximity Read ↗

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