Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2015

Brun Pierre-Jacques, Grijalva Ambar, Rausch Richard, Watson Elizabeth, Yuen Jason J, Das Bhaskar C, Shudo Koichi, Kagechika Hiroyuki, Leibel Rudolph L, Blaner William S

Abstract excerpt

Retinoic acid signaling is required for maintaining a range of cellular processes, including cell differentiation, proliferation, and apoptosis. We investigated the actions of all-trans-retinoic acid (atRA) signaling in pancreatic β-cells of adult mice. atRA signaling was ablated in β-cells by overexpressing a dominant-negative retinoic acid receptor (RAR)-α mutant (RARdn) using an inducible Cre-Lox system under...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Insulin-Secreting Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin Secretion

Share to Integrases

Share to Islets of Langerhans

Share to Receptors, Retinoic Acid

Share to Retinoic Acid Receptor alpha

Share to Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 25389133
DOI: 10.1096/fj.14-256743
PMCID: PMC4314234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass.PMID 25389133Read ↗

Reduced Retinoic Acid Receptor Beta (Rarβ) Affects Pancreatic β-Cell PhysiologySemantic proximity Read ↗

Retinoic Acid Promotes the Generation of Pancreatic Endocrine Progenitor Cells and Their Further Differentiation into β-CellsSemantic proximity Read ↗

Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specificationSemantic proximity Read ↗

Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor.Semantic proximity Read ↗

Increased TGF β /Activin-Smad2 signaling is associated with pancreatic β -cell dysfunction and glucose intolerance in gestational diabetes mellitusSemantic proximity Read ↗

The Developmental Regulator Pax6 Is Essential for Maintenance of Islet Cell Function in the Adult Mouse PancreasSemantic proximity Read ↗

GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells.Semantic proximity Read ↗

Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.Semantic proximity Read ↗

Research Resource: Nuclear Hormone Receptor Expression in the Endocrine PancreasSemantic proximity Read ↗

Hepatic β-arrestin 2 is essential for maintaining euglycemia.Semantic proximity Read ↗

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.Semantic proximity Read ↗

Decreased IGF1R attenuates senescence and improves function in pancreatic β-cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.