Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice

18 May 2004

Abstract excerpt

Growth hormone, acting through its receptor (GHR), plays an important role in carbohydrate metabolism and in promoting postnatal growth. GHR gene-deficient (GHR(-/-)) mice exhibit severe growth retardation and proportionate dwarfism. To assess the physiological relevance of growth hormone actions, GHR(-/-) mice were used to investigate their phenotype in glucose metabolism and pancreatic islet function. Adult...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Growth Hormone and Insulin-like Growth Factors
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15138153
DOI: 10.1152/ajpendo.00423.2003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in micePMID 15138153Read ↗

Deconstructing the Growth Hormone Receptor(GHR): Physical and Metabolic Phenotypes of Tissue-Specific GHR Gene-Disrupted Mice.Semantic proximity Read ↗

Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.Semantic proximity Read ↗

Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.Semantic proximity Read ↗

Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in FemalesSemantic proximity Read ↗

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)Semantic proximity Read ↗

Tissue-Specific GHR Knockout Mice: Metabolic PhenotypesSemantic proximity Read ↗

Islet function phenotype in gastrin-releasing peptide receptor gene-deficient mice.Semantic proximity Read ↗

Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging.Semantic proximity Read ↗

Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.Semantic proximity Read ↗

Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans?Semantic proximity Read ↗

Growth hormone receptor/binding protein (GHR/BP) knockout mice: a 3-year update.Semantic proximity Read ↗

Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.