Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.

doi:10.2337/diabetes.48.10.1979

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Article

Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.

Diabetes - 1 Oct 1999

Flamez D, Gilon P, Moens K, Van Breusegem A, Delmeire D, Scrocchi L A, Henquin J C, Drucker D J, Schuit F

Abstract excerpt

1-Cells from rodents and humans express different receptors recognizing hormones of the secretin-glucagon family, which--when activated--synergize with glucose in the control of insulin release. We have recently reported that isolated islets from mice homozygous for a GLP-1 receptor null mutation (GLP-1R(-/-)) exhibit a well-preserved insulin-secretory response to glucose. This observation can be interpreted in...

Topics

Acetylcholine
Animals
Calcium
Cells, Cultured
Cyclic AMP
Diazoxide
Female
Glucagon-Like Peptide-1 Receptor
Glucose
Islets of Langerhans
Male
Mice
Mice, Knockout
Peptide Fragments
Phenotype

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Open in PubMed

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PMID: 10512362
DOI: 10.2337/diabetes.48.10.1979

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Receptors, Glucagon

Signal Transduction