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Article

β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice.

Cardiovascular diabetology - 17 Jul 2018

Tauscher Sabine, Nakagawa Hitoshi, Völker Katharina, Werner Franziska, Krebes Lisa, Potapenko Tamara, Doose Sören, Birkenfeld Andreas L, Baba Hideo A, Kuhn Michaela

Abstract excerpt

BACKGROUND: The cardiac hormones atrial (ANP) and B-type natriuretic peptides (BNP) moderate arterial blood pressure and improve energy metabolism as well as insulin sensitivity via their shared cGMP-producing guanylyl cyclase-A (GC-A) receptor. Obesity is associated with impaired NP/GC-A/cGMP signaling, which possibly contributes to the development of type 2 diabetes and its cardiometabolic complications. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30016962
DOI: 10.1186/s12933-018-0747-3
PMCID: PMC6048747

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