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gamma-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells.

Free radical biology & medicine - 15 Apr 2006

Zhang Hongqiao, Liu Honglei, Dickinson Dale A, Liu Rui-Ming, Postlethwait Edward M, Laperche Yannick, Forman Henry Jay

Abstract excerpt

gamma-Glutamyl transpeptidase (GGT) plays key roles in glutathione homeostasis and metabolism of glutathione S-conjugates. Rat GGT is transcribed via five tandemly arranged promoters into seven transcripts. The transcription of mRNA V is controlled by promoter 5. Previously we found that GGT mRNA V-2 was responsible for the induction of GGT in rat alveolar epithelial cells by 4-hydroxynonenal (HNE). In the...

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PMID: 16631518
DOI: 10.1016/j.freeradbiomed.2005.11.005
PMCID: PMC2702664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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